PhD candidate ‘Towards brain-protective ventilation in critically ill patients (BRAIN-VENT)’

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Jouw functie

Mechanical ventilation is a life-saving intervention for critically ill patients in the intensive care unit. While essential for survival, it is strongly associated with brain dysfunction, including delirium, dyspnea, and persistent cognitive impairment. To minimize these harmful effects, we urgently need novel brain-protective ventilation strategies. The mechanisms linking mechanical ventilation to brain dysfunction remain poorly understood. A critical, yet largely overlooked, factor is the modulatory role of breathing on brain activity. Physiological breathing rhythmically shapes neural oscillations and is fundamentally intertwined with cognitive and affective processes. Mechanical ventilation profoundly alters natural breathing dynamics, potentially disrupting respiratory–brain coupling and thereby contributing to brain dysfunction.

In this ZonMw Vidi-funded PhD project (BRAIN-VENT), you will work at the cutting edge of respiratory neurophysiology and intensive care medicine. The project aims to generate transformative insights into ventilator-induced brain dysfunction and to pioneer innovative strategies to restore respiratory–brain coupling in mechanically ventilated patients. By adopting a brain-centered perspective on mechanical ventilation, you will redefine mechanical ventilation practice and improve outcomes in critically ill patients.

As a PhD candidate, you will:

  • Design and conduct experimental and clinical studies on respiratory-brain coupling.
  • Develop novel neurophysiological biomarkers of respiratory-brain coupling.
  • Acquire and analyze multimodal neurophysiological data, including high-density EEG and fMRI.
  • Apply advanced signal processing and quantitative analysis techniques to characterize neural oscillations and brain–breathing interactions.
  • Interpret experimental data and present findings at international meetings and conferences.
  • Contribute to scientific publications and your PhD thesis.
  • Collaborate closely with a multidisciplinary team, including technical physicians, intensivists and neuroscientists.

Jouw werkplek

You will be embedded in the 'Respiratory Failure and Mechanical Ventilation' research group at the Department of Intensive Care, Radboud university medical center (Radboudumc) in Nijmegen, a leading center for patient care, biomedical research, and education. The 'Respiratory Failure and Mechanical Ventilation' research group is at the forefront of acute respiratory failure and mechanical ventilation research, spanning fundamental to large-scale clinical studies. The research group not only provides expertise but also offers mentorship, global collaboration opportunities, and technical guidance - making it an ideal environment for conducting world-class research in intensive care.

You will work in an environment where basic scientists and clinicians closely interact, enabling real translational impact. The team consists of motivated PhD candidates, postdocs, technicians, and clinician-scientists who support each other’s development and success.

Jouw profiel

You are a highly motivated and analytically minded candidate with a strong interest in brain connectivity, quantitative methodologies, and translational research involving both patients and healthy participants. You combine curiosity with methodological precision and have a demonstrable affinity for complex neurophysiological data.

You are capable of working independently, taking ownership of projects from design through analysis and dissemination, while also functioning effectively within a multidisciplinary team. Strong organizational and communication skills enable you to manage research activities and collaborate across disciplines. Persistence, resilience, and a critical scientific mindset characterize your approach to research and problem-solving.

Essential qualifications

  • A completed Master’s degree in neuroscience, biomedical engineering, technical medicine, data science, or a closely related discipline.
  • Strong quantitative and analytical skills, or a clear and demonstrable motivation to further develop advanced methodological expertise.
  • Hands-on experience with EEG acquisition and/or analysis, including brain network or connectivity analysis.
  • Programming and data analysis experience (e.g., Python, MATLAB, R) in a research context.
  • Excellent command of spoken and written English.

Desirable qualifications

  • Prior experience with MRI or multimodal neuroimaging data analysis.
  • Proficiency in Python-based scientific computing (e.g., NumPy, SciPy, MNE, pandas, scikit-learn).
  • Familiarity with multivariate statistical methods, network analysis, computational modeling, or machine learning approaches applied to neurophysiological data.
  • Interest in respiratory physiology, intensive care medicine, and mechanical ventilation.

Goed om te weten

  • This position requires a Certificate of Conduct (VOG).

Meer weten?

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Jonne Doorduin

+31650155757

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