PhD candidate 'Developing antisense oligonucleotide treatments for metabolic disease'

At Radboudumc, you will work in a highly collaborative, interdisciplinary, and international environment. We are a leading European center for genomic medicine and rare disease research, with strong connections to clinicians, patients, and European initiatives such as ERDERA. What sets us apart is our unique position at the interface of fundamental research on metabolomics and advanced model systems and translational research on (genetic) treatments involving clinicians and patients. This ensures that your work will have clinical relevance and impact.

You will join a group that performs preclinical research on genetic metabolic disorders aiming to improve diagnostics, understand disease mechanisms and develop treatments. Our team consists of senior scientists, technicians and PhD students and post-docs with multidisciplinary expertise of metabolomics, iPSC based disease models, therapeutics and molecular genetics.

The position is based at Radboudumc in Nijmegen, the Netherlands. Radboudumc is internationally renowned for its research and diagnostics on a variety of genetic disorders and the impact of personalized medicine. The position is primarly housed in the department of Human Genetics with a strong collaboration with Pediatrics. Both departments offer an exciting working environment with enthusiastic people from many parts of the world, providing ample critical mass and a stimulating, collaborative atmosphere for high quality research.

You bring curiosity, creativity, and energy to the table. You are proactive and take initiative, and highly value collaboration with team members and other people within our department. You are motivated, communicative, hard-working, and adaptable, while keeping your eye on the team's goals.

Your ideal profile:

• Completed a MSc degree in Molecular Life Sciences or a related field.
• Solid theoretical background in molecular and cell biology, as well as hands-on experience with standard molecular techniques such as PCR, cloning, RT-PCR, western blotting, cell culture and stem cell technology. Experience with molecular therapy, in particular, antisense technology, will be considered a strong plus.
• Preferable experience with metabolism.
• Self-motivated, project-oriented work ethic with collaborative and team player attitude.
• Effective communication, writing and presentation skills in English for multidisciplinary audience.

• The first job interviews will take place on April 23, 2026 (online). The second job interviews will take place on May 8, 2026 (in person). Please take this into account.
• This position requires a Certificate of Conduct (VOG).